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首頁(yè)> 外文OA文獻(xiàn) >Analysis of interactions among purified components of the liver microsomal cytochrome P-450-containing monooxygenase system by second derivative spectroscopy
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Analysis of interactions among purified components of the liver microsomal cytochrome P-450-containing monooxygenase system by second derivative spectroscopy

機(jī)譯：用二階導(dǎo)數(shù)光譜法分析含肝微粒體細(xì)胞色素p-450的單加氧酶系統(tǒng)純化組分的相互作用

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摘要

Second derivative spectroscopy together with the respective difference spectroscopy offers an effective methodical tool to resolve overlapping bands and shoulders into distinct bands at eliminated background absorption. The improved resolution allows attribution of the distinct bands to individual amino acid residues. Both methods have been utilized to analyze interactions between the three essential components of the liver microsomal cytochrome P-450-containing monooxygenase system. The improved resolution of the aromatic amino acid residues in the derivative spectra of cytochrome P-450LM2 and reductase allows one to determine that in the interactions of the essential components tyrosine residue(s) are involved. The participation of phenylalanine is likely and the participation of tryptophan residues is excluded. The pH-dependent decrease of the tyrosine absorption bands in the medium ultra-violet region with increasing pH is accompanied by a concurrent decrease of the heme absorption in the Soret region. Based on this concurrence, the existence of a heme-linked tyrosine as one of the axial heme iron ligands in cytochrome P-450 is postulated.
機(jī)譯：二階導(dǎo)數(shù)光譜以及各自的差異光譜提供了一種有效的方法論工具，可在消除背景吸收的情況下將重疊的譜帶和譜肩拆分為不同的譜帶。改善的分辨率允許將不同的條帶歸因于單個(gè)氨基酸殘基。兩種方法均已用于分析含肝微粒體細(xì)胞色素P-450的單加氧酶系統(tǒng)的三個(gè)基本成分之間的相互作用。在細(xì)胞色素P-450LM2和還原酶的衍生光譜中，芳香族氨基酸殘基的改善分辨率使得人們可以確定，在必需成分的相互作用中，酪氨酸殘基涉及到。苯丙氨酸可能參與，色氨酸殘基的參與被排除在外。 pH值升高時(shí)，中紫外線區(qū)域酪氨酸吸收帶的pH依賴性降低伴隨著Soret區(qū)域血紅素吸收的同時(shí)降低。基于這種同意，推測(cè)存在血紅素連接的酪氨酸作為細(xì)胞色素P-450中軸向血紅素鐵配體之一。

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